Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion

Abstract We hypothesized the smoothness of border between inner nuclear layer (INL) and outer plexiform (OPL) associates with frequency macular edema (ME) recurrences secondary to branch retinal vein occlusion (BRVO). Thirty-seven consecutive eyes BRVO treated anti-vascular endothelial growth factor (VEGF) injections at 1-year follow-up were included. manually traced INL OPL within 1.5-mm vertical line from fovea on optical coherence tomography (OCT) images initial visit. The jagged ratio (JR), length divided by spline curve length, was calculated. performed univariate multivariate regression analyses, including JR, patient characteristics, number cystoid spaces in INL, area, retina area. Multivariate analysis showed JR significantly correlates total anti-VEGF ( P < 0.0001). Moreover, mean lower nine receiving two or fewer than 28 three more (1.02 ± 0.01 vs. 1.13 0.06, A smooth OCT visit may be a biomarker for ME BRVO.